How the dangers of e-cigarettes extend beyond DNA damage

Studies done on laboratory mice suggest that e-cigarettes can be harmful to humans, although to a lesser degree compared to the traditional tobacco they are supposed to replace. This suggests that  cigarette smokers could do themselves some good in switching to e-cigarettes, although those who have yet to pick up the habit should avoid it because it can actually do the body harm – and is not zero-risk smoking as some might view it.

E-cigarettes have been growing in use over the last few years. Because they are aerosol-based, they use compounds to deliver nicotine to the user. This means they avoid the smoke associated with traditional tobacco cigarettes. In the latter, the burning of tobacco releases carcinogens, which cause cell damage and cancer when they are inhaled. The delivery of nicotine by aerosol in e-cigarettes avoids these, although the recent study proposes that this is not enough.

The most recent research into the use of e-cigarettes suggests that they still cause cancer because they damage string DNA and the body’s ability to repair itself.

Laboratory mice were exposed to the vapour of e-cigarettes for a period that simulated normal human consumption. The vapour of e-cigarettes contains both nicotine and solvent, and while the solvent itself had no effect on the mice, the combination of solvent and nicotine had the same impact as nicotine itself.

The limitations of the study were that it was unclear the vapour inhaled by the mice was equal to the amount a human being would, or pro-rated for the difference in mass! Furthermore, the impact on mice may not be comparable to those on humans.

The research does highlight, nevertheless, that there is a potential danger in e-cigarettes. While guidelines in 2016 recommended them as a safer alternative to tobacco, they are not 100% safe. Various groups of people such as the younger generation, for whom smoking is a perceived sign of maturity, think that just because there is no burnt substance, that they are perfectly safe. Unfortunately, the easy availability of these e-cigarettes, just like nicotine gum, means that rather than getting individuals off cigarettes, they may only be building up a lifelong addiction instead.